How about those Glial Cells

Thursday, July 2nd, 2009

For many years neurons have been considered the main act within the cerebral cortex, responsible for our thoughts, emotions, and movements. Of interest is the fact that neurons only account for about 10% of human brain cells. Glial cells that account for the other 90% of brain cells have typically been thought to carry a supportive role to the neurons.

An article in Forbes Magazine (July 13, 2009), however, suggests glial cells may be even  more important than neurons for treating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and stroke. Recent understanding of the brain now indicates glial cells with neurons play a critical role in brain development and brain function.

Medications on the market today do not work on glial cells. Ben Barnes, Chairman of the Neurobiology Department at Stanford University Medical School posits that one type of glial cells, the astrocytes, trigger the initial steps of destruction in brain diseases. As such, Dr. Barnes believes that by creating treatments that of the astrocytes can in turn save dying neurons.

If glial cells do indeed maintain a more critical role in the formation, function, and elimination of synaptic activity, plasticity, and creation of myelin sheath around the neuron, an entirely new approach to behavioral neuroscience will be born and with it, an entirely new treatment approach.

When Shopping is not Shopping

Wednesday, June 24th, 2009

womenandmenshopping

A typical and yet interesting reality is that most women enjoy shopping and most men do not. As one interested in human behavior this is a fascinating finding worthy of some curiosity. The explanation of the differences between the two genders regarding shopping might be found in a basic understanding of the human brain.

Shopping for a male brain is defined as going into a store or mall, selecting the item to be purchased, and getting out of the store as fast as possible. This behavior is task-based, something to be confronted and completed. The male brain operates primarily within the dominant hemisphere, a side of the brain that is task based.

Shopping for a female brain is both task based and process based. For example, a female can do the same thing a male does while shopping by getting the item and getting out. However, upon entering the doors of the mall, the female brain hears music in the background, smells cinnamon rolls baking in the distance, and appreciates the wonderful different colors and textures of the products throughout the store. This is the non-dominant side of the female brain functioning, something that is foreign to the male brain within the shopping mall.

It can be fun to watch the female and male brain try to work together as “shopping” behavior occurs together. Have you ever seen an otherwise happy couple get frustrated with each other in the mall? Perhaps a little understanding of the how and why behind the gender differences can help to make the next shopping trip a good one.

Emotional Eating

Monday, June 22nd, 2009

We eat for many different reasons some of which are not healthy. Food is necessary for humans to survive though consumption of food in advanced nations is really not based on survival. Early in our development we hunted and remained vigilant most of the day to gather and consume food for survival. Today, food is so available in many different forms that this primal instinct to eat for survival is gone.

Today, food is consumed to satisfy hunger, maintain a routine of three meals a day, and to cope with emotions of guilt, anxiety, sadness, boredom, low self esteem, anger, and loneliness. Emotional eating is probably never healthy and leads to other problems such as obesity, high blood pressure, high cholesterol, and diabetes. These problems in turn lead to increased risk for heart attack, stroke, and even dementia.

The only way to identify why you are eating is to remain conscious of your thoughts and feelings when you desire food. This will help you understand what is driving you to eat. Clearly we need to consume food for energy and function. However, most people over consume and do so on a subconscious basis. This unhealthy regimen can be addressed and transitioned to a healthy regimen of eating behavior only by becoming conscious of one’s thoughts prior to eating

Here are some activities to promote and stabalize emotional balance

Music as medicine: Docs use tunes as treatment

Tuesday, June 2nd, 2009

Listen carefully and you’ll hear the same refrain at a rising number of hospitals. From Massachusetts General to the Mayo Clinic, patients are hearing the first strains of a harmonious movement — the infusion and inclusion of music in the treatment of ailments, from brain disorders to cancer. This goes beyond the psychological smile favorite songs can induce.

Doctors are increasingly studying — and employing — the physiological dance music does with the body’s neurons and blood-carrying cells.

Researchers explore how melodies can help regulate heart, boost hormones

Traumatic Brain Injury and Recovery

Thursday, May 28th, 2009

I am often asked clinical questions pertaining to traumatic brain injury (TBI). There are two major types of TBI that include closed head injury (CHI) in which the skull is struck and does not fracture. The second type is known as open head injury in which the skull is struck and fractures (split the head open). Sometimes an open head injury is advantageous as it permits room for the predictable swelling or edema that occurs with head injuries. The problem with an open head injury is high risk for infection.

Closed head injuries are caused by a blow to the head from a motor vehicle accident, sports such as football, hockey, and even soccer, falls, and being hit by an instrument or other object. The brain sits in a liquid medium called cerebral spinal fluid and it will move inside the skull with an accelerating and then decelerating force. The brain can be injured at the site of the trauma (coup) and also on the opposite side of the brain as it moves in the liquid medium and hits against the skull (contracoup). As the skull is most rugged in the front and temporal skull regions with a smoother surface in the rear of the skull, it is common to experience cognitive and behavioral changes related to damage in the fronto-temporal region.

Such changes in cognition from a closed head injury typically involve memory, attention, and personality change. It is difficult to predict behavioral and cognitive changes related to open head injuries until the site of the damage is clearly known. Other factors such as loss and duration of loss of consciousness and memory loss that predates the time of the injury (retrograde amnesia) and post-dates the injury (anterograde amnesia) relate to extent and severity of the brain injury.

Treatment for TBI includes medication, surgery, speech, occupational, and physical therapy, and time. Improved function and cognition occurs primarily in the first year post injury, but improvement can continue to occur into the third year. Little is known about the effects of a proactive brain health lifestyle and or the consistent use of cognitive-based mental exercise software on recovery. This is an empirical question that is generating interest and attention.

The brain will heal to some degree, hopefully to a complete recovery, and one should not discount lifestyle for brain health and use of cognitive exercises to help in the process.

Implications of Poverty on the Brain

Tuesday, May 26th, 2009

Most advanced nations spend a significant amount of time, money, and energy dealing with poverty and the short and long term consequences for those who live in poverty. Policy statements are drafted and then implemented with varying degrees of success. One thing is certain, no policy has removed poverty suggesting that we either have not implemented the correct policy or poverty is a reality of life.

One aspect of poverty that probably does not receive enough attention is the negative health outcomes that result from such an environment. Studies many years ago demonstrated the negative effects of an un-enriched environment on rats. Interestingly, the brain was significantly affected both structurally and functionally. For humans, poverty really represents an unenriched environment in which poor nutrition, lack of love and attention, crime, drugs, insecurity, and lack of proper mental stimulation exist.

A nation enlightened to development of our youth and to creation of a policy that understands the impact of poverty will confront this reality. Research has demonstrated a correlation between poverty in childhood and increased risk for Alzheimer’s disease later in life. While there are short term consequences of poverty, there are also long term effects particularly when one understands that poverty limits proper development of the human brain.

Perhaps a first step in creating a policy on poverty is to educate the public on the importance of environmental input early in life upon later development of the human brain. Most families will work to follow such educational guidelines if they understand what to do with regard to promoting brain health for their own children. For those who are vulnerable and without resources or adults to provide the enriched environment policies can address what is needed and appropriate resources to help developing children thrive.

Exercise is not only good for the heart and lungs, it can keep the brain healthy.

Tuesday, May 19th, 2009

Studies show that those who exercise the most have bigger brain volumes in key areas than those who do not. Keeping fit may also slow the rate of age-related decline in the brain.

In the trial, 52 healthy men and women had their brains scanned, were interviewed and had their exercise data collected.

Brain volume in key areas  -  including the temporal lobe which is involved in language, memory and emotion  -  were significantly lower in those who did the least exercise, say the American researchers.

It’s thought exercise boosts the growth and development of brain cells.

Read more about Excercise and Brain Health

Is it Alzheimer’s or just normal aging?

Thursday, April 23rd, 2009

I am frequently asked what the difference is between memory changes associated with normal aging and that related to Alzheimer’s disease (AD). First, the memory changes associated with normal aging are not a disease. The typical pattern of memory change with advanced age is a deficit in retrieval. A healthy older brain can encode information because the hippocampus is relatively healthy. This permits new information to be encoded. The older adult has some difficulty retrieving that new information, but with cues and prompts they retrieve the information as well as those in their thirties.

In contrast, a brain with AD has a damaged hippocampus that prevents new information from being encoded. This means that new learning does not take place and that cures and prompts do not help because the information is not there to be prompted.

In general, a healthy older adult encodes new information, but needs some help in retrieving what has been encoded. A brain with AD does not encode new information and therefore cues and prompts will not help with retrieval.

Fore more information about Alzheimer’s Disease

I keep forgetting names!

Wednesday, April 22nd, 2009

It is very common to be introduced to a new person, to hear their name, and to rapidly forget the person’s name. The question is why?

Is this experience a reflection of you having a poor memory? It actually might represent an attention problem. When we meet new people for the first time there is a tremendous amount of information being processed, outside factors that may be distracting, and each person is generally concerned about him or herself.

Word finding difficulty or the inability to derive a name that was just presented to you is not a sign of disease, but a probable indication that you can benefit from specific tips to remember the names.

As an example, when someone introduces himself or herself to you recite the name aloud and repeat it in every sentence you communicate to the person. This will facilitate a deeper encoding of the name initially which helps to store the information more permanently.

To learn more about Brain Health

Diabetes and Dementia

Monday, April 20th, 2009

A recent study in Journal of the American Medical Association provides further support for a relationship between the risk factors of type II diabetes and dementia. This particular study focused on episodes of hypoglycemia and its influence on risk for dementia.

With diabetes there exist a number of health related factors such as obesity, imbalance of glucose, high blood pressure, stroke, abnormal cerebrovascular flow, and heart and other major system dysfunction. Either these factors combined or with a focus on glucose stabilization which can adversely affect the function of neurons, there appears to be a critical risk enhancement to development of dementia in later life.

The important point here is that diabetes with all of its risk factors are cumulative and have a proactive and lifelong effect. This underscores the need for a proactive and lifelong healthy lifestyle, including that for the brain. Nutrition and physical activity are two primary lifestyle behaviors critical for combating type II diabetes.

Eating brain healthy foods and remaining physically active to enhance blood flow to the brain are both necessary and fundamental to a healthy lifestyle and to combating the risk for type II diabetes.