German Scientists Test New Way to Combat Alzheimer’s

German scientists have found success in reversing the plaque buildup in brains of mice. The plaque deposits are one of the hallmark features of Alzheimer’s disease (AD) and this finding may lead to viable treatments for humans.

The compound reportedly effectively blocks an enzyme responsible for development of the plaque. The compound attaches itself at the precise site on the cell wall where the toxic action occurs.

When injected directly into the brains of mice, scientists indicate the compound works well. The next step is to determine if the compound can cross the blood brain barrier, the protective shield around the brain. Animal tests have begun to determine if medicines given by mouth or injection have the high rate of efficacy as direct injection into the brain where there was a 50% reduction in plaque formation within four hours. Scientists believe that if the testing on animals goes well a human version could be available in five to ten years.

Size Might Just Matter After All

We have known for some time that some persons do not manifest the clinical pathology of Alzheimer’s disease (AD) even though their brains have the hallmark plaques and tangles at autopsy. How this occurs is still not known, but one theory is that those persons who are able to fight the clinical aspects of the disease off may have more brain reserve, developed over the course of their lifetime. It is further thought that particular lifestyle factors such as exposure to enriched, novel and complex environments can help to build reserve.

A new study indicates that the size of the hippocampus, the structures that lie deep in the temporal lobe and help to form new memories and learning, may be important. Researchers at Oregon Health and Science University in Portland found that those persons who avoided dementia had larger hippocampi relative to those who did not avoid the manifestation of the disease. Both groups had the pathologic markers of AD.

Interestingly, the researchers did not find any difference in the two groups on education level or socioeconomic status. However, the study did not explore what the person did in their lifetime, the type of activities he or she pursued, or the quality of learning after graduation. While education level has correlated with reduction in the risk of dementia in other studies, the hippocampus may be stimulated by much more than formal education.

This is most likely the case given the research in 1998 that found the human hippocampus can generate new brain cells. Our goal should be to grow larger hippocampi through enriched environments across our lifetime as a health promoting behavior (see Dr. Nussbaum’s brain health lifestyle www.paulnussbaum.com). In this case, it is to potentially delay onset of dementia.

Curiosity of Mental Energy

Everyone experiences moments when we feel sluggish or perhaps hyperactive. Sometimes our brains feel like they are stuck in mud while other times we can solve almost any problem we confront. Interestingly, these cycles of mental energy or arousal may occur within a 24 hour time period, our circadian rhythm.

Some of us have our creative time or the time we perform best mentally in the morning hours. Others have their greatness expressed in the evening hours. There is no right versus wrong, simply different. Some people who work after midnight or in a mine shaft that has no natural light can experience a different circadian rhythm than those who work during the day and have exposure to natural sunlight. Sleep disorders, depression, and cognitive problems can result from altered sleep wake cycles.

There is no clear explanation for when arousal is highest in some and lowest for others. Some factors that can enhance or reduce mental energy or arousal include the following:

  • Amount of daily exercise
  • Amount of sleep in 24 hours
  • Types of foods consumed
  • Water intake and hydration
  • Exposure to sunlight
  • Prescribed Medication and substance abuse
  • Mental challenge during the day

One of the best methods to increase mental energy is to increase blood flow to the brain through movement. This can include a brisk walk, aerobics, brain games, swimming, and even a dance. Fresh air can also rejuvenate a sluggish brain and increase water intake to remain hydrated during the day. Sugar can put the brain to sleep in some cases or make it feel like a good nap is needed. Caffeine can provide a quick boost, but may result in a type of mental crash later in the day.

It is a good idea to first identify what periods of the day your brain is alert and productive and when it is sluggish. Try to identify what factors might be causing the onset of sluggishness and consider the brain tips suggested above.

A mentally alert brain is critical to health and to productivity.

Creativity and the Brain

The human brain left to its own would likely create in unthinkable ways. Creativity most likely occurs when structure is limited and free flow of cognition can take place. It is suggested that Einstein’s most creative moments occurred when he took his morning walk or bike ride.

Recent research suggests creativity relates to advanced age. It is important to note that older brains tend to lose a disproportionate number of brain cells in the frontal lobe, the area of the brain that helps to impose structure in our lives and perhaps on our thinking. With less capacity to impose structure, creativity may be unleashed.

Given this, it is interesting to consider how much brain expression our world suppresses. Our classrooms impose enormous structure as do our jobs. We are highly routinized animals and probably rely as much on our subcortical brain regions as we do our cortex. We tend to refrain from new experiences or pathways to a similar endpoint. We also do not free our brains from structure long enough to express creativity.

It is important to provide your brain with some time to simply think or exist without any task to be completed. Such time may help the brain express itself in ways it otherwise cannot. One prescription is to give your self 30 minutes a day of quiet or idle time. Einstein used such time to take a walk or ride a bike. By releasing structural restraints on your brain, you may create an entire new reality and future for your self and for others.

Mood and Cognitive Functions

Your brain operates electrically and chemically. Neurochemicals form the dynamic foundation for our thoughts and emotions. Many neurochemicals have been identified while many more have not. Neurochemicals important to mood include Serotonin, Neuropinephrine, Neuroadrenaline, and Dopamine. These neurochemicals remain in healthy balance for most of us, but for some there is imbalance and a mood disorder can result.

Effects of a mood disorder such as depression or mania include functional decline, interpersonal difficulty, and cognitive impairment. Depression is far more common than realized and represents a major chronic illness similar to high blood pressure. Depression not only affects the specific person, but it can also affect negatively those close to the patient and to potential colleagues. Depression and mania impairs thinking by reducing focus, attention, memory, and ability to execute plans. A depressed brain cannot process as deeply as necessary and this can result in rather significant cognitive impairment at times. Uncontrolled mania results in high distractibility, poor attention, and generally impaired cognitive functions across the board.

Treatments for mood disorder are effective and include use of antidepressants, mood stabilizers for mania, psychotherapy, and following a brain health lifestyle as espoused by Dr. Nussbaum (www.paulnussbaum.com). Use of software similar to that of FitBrains that helps to stimulate mental activity can also be of some use for a brain that may be sluggish. The most important thing is to first identify depression when it arises, take it seriously, and get some help.