Of Mice and Fries

A new study found mice that consumed junk food for nine months demonstrated signs of the abnormal brain tangles typically associated with Alzheimer’s disease (AD). Indeed, a diet rich in fat, sugar, and cholesterol could increase the risk of the most common type of dementia.

The study published by the Karolinska Institute’s Alzheimer’s Disease Research Center found a chemical change in the brains that were fed the unhealthy diet, not unlike that found in the AD brain.

The researchers suggest a high intake of fat and cholesterol in combination with genetic predisposition can adversely affect several brain substances that may contribute to onset of AD.

The combination of the gene type APOE-4, found in 15 to 20 percent of people and a known risk factor for AD, and the diet rich in fat, sugar and cholesterol led to the abnormal build up of the protein Tau and tangles. Interestingly, the animals also demonstrated reduced levels of another protein called Arc involved in memory storage.

The results offer another hint that AD may be attacked by lifestyle (diet) prior to its onset and progressive damage.

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