Category Archives: Brain Science

Interesting facts about your brain and how to keep it fit!

Brain Reserve is Worth Building!

Interest in the human brain is at an all time high with both scientists and the general public reading, learning, and writing more about this great system. There is much discussion and even tension about what the brain can and cannot do, whether it has certain capacities or not, and what can be stated with some confidence and what cannot.

While it is true we need to conduct more, well designed, controlled studies, certain things are true of the brain today:

1.    The human brain is the most complicated and brilliant system known.
2.    The human brain has plasticity which means it can be shaped, is dynamic, and constantly reorganizing.
3.    The human brain generates brain cells in the hippocampus and most likely the olfactory system.
4.    Cognition changes as we get older, but there remains great variability particularly at the oldest of age.
5.    Proactive lifestyle factors relate to improved brain health.
6.    Brain reserve continues to gain support as a mechanism to delay onset of dementia.

The latter point was reinforced yesterday in a major article in the USA Today (9-2-10) that described a study that will be published in Neurology. A research team at Rush Presbyterian conducted a 12 year study that evaluated the mental activities of 1,157 people 65 years of age and older who did not demonstrate dementia at the start of the study. Study participants were assessed at the beginning of the study and again for Alzheimer’s at the six-year period. After that, each participated was evaluated every three years to measure how often they participated in activities such as reading, listening to the radio, playing games and going to the museum. A five point scale was used with more points earned for more frequent participation in mentally stimulating activities.

Results indicated the rate of cognitive decline for persons without dementia was reduced by 52% for each point on the cognitive activity scale. For persons with Alzheimer’s the average rate of decline per year increased by 42% for each point on the same scale. The research team described their findings using the cognitive construct of “cognitive or brain reserve” which suggests that an active and stimulated brain creates new neural pathways which over time can help to delay onset of neurodegenerative diseases such as Alzheimer’s. This is not a cure.

Researchers were less clear why persons who are mentally active demonstrate a rapid decline once Alzheimer’s manifests. One idea might be that reserve helps to delay onset of Alzheimer’s, but once the disease manifests clinically it is already in an advanced stage with an accelerated rate of decline. The good news for this study is that there is benefit to the brain from remaining mentally stimulated across the lifespan. Brain reserve is something worth building.

Napping and the Brain

Sleep has been known to be an important component to brain function and memory for some time. A recent study on sleep and learning conducted by Dr. Walker, University of California Berkeley provides further support.

The study involved 39 healthy young persons who were placed into a nap or no nap group. At noon, all subjects completed a memory task intended to engage the hippocampus, a region deep in the medial temporal lobe responsible for learning new fact based information. Both groups performed equally on this test.

At 2pm, the nap group took a 90 minute nap while the no-nap group did not. At 6pm of that day, subjects completed a new memory task. Those who remained awake throughout the day performed worse on the task while those who napped did markedly better and actually improved in their capacity to learn.

Some scientists suggest the human animal is designed to sleep in bouts rather than one long period of time which supports taking naps. About 30% of Americans nap during the mid-day. The study’s results support the idea that sleep clears the brain’s short-term memory storage and creates the ability for new information to be learned. Napping may serve as a type of “rebooting” process, particularly when nappers enter stage two of their natural sleep cycle.

Results are preliminary and further research will be done to support these findings. However, scientists continue to help understand the sleep and its critical role in memory and brain health.

Sweet dreams!

Visualization and the Human Brain

You may have heard about the ability to “see one’s future” or maybe to “see yourself achieving a goal or success.” For some this may seem purely science fiction. However, it is important to not fall victim to the common tendency of many to underestimate the power of the human brain. You might be surprised to learn that many of the coincidences or “déjà vu” phenomena that occur in your life are brain based and directed.

Visualization is the term often used to describe our attempt to use mental imagery to guide behavior and outcome. This is used by many of our best known athletes and others who are the best at what they do. Very often it is the mental side of action that differentiates good from great.

Specific steps to practice visualization include the following:

1.    Identify a specific goal you have for your life, one that you have some control     over shaping. Specify what a successful outcome is for attaining your goal. Place     that goal into your brain and specify when it should occur. Identify those things     and people you need to have to reach the goal.

2.    Identify impediments to the goal including those that may exist outside of you and     those inside of you. The latter involve your own tendencies that may have limited     your success in the past. It might be lack of confidence, poor persistence,     problems dealing with setbacks, etc.

3.    Once steps 1 and 2 are completed, position yourself into a quiet area where you     can engage in deep breathing relaxation and meditation. On a daily basis you need     to turn inward and learn to set your body and brain into a relaxed state of     existence. You will need to practice these two-to-three times daily to learn how to     relax. You should feel completely at ease and focused on your existence.

4.    Once you are mentally relaxed and focused inward without any external     distraction, you can begin to see yourself completing the goal you identified. You     can visualize success, see the people and things that will help you to achieve     success, and feel the success. Your brain needs to establish the reality of the     success and map out the road to the desired outcome. The singular focus is on     success.

5.    Now you are ready to simply live your life and to realize your surroundings more     consciously. Life will provide the path for your goal and your brain understands     what to do because of your visualization training.  You may need to stop what you     are doing and re-engage in the visualization process above. If you remain true to     these steps you will find greater sense of accomplishment and goal attainment in     your life. It takes time. Visualization is a lifestyle change.

Our Moods in the Winter Months

The winter of 2010 has been particularly rough or impressive depending on your frame of reference. Having spent 10 years in Tucson, Arizona and now living in the eastern part of the United States, I am on the side of “rough.” For millions of people all across the planet, the winter of 2010 has caused school closings, car accidents, loss of power, plenty of exercise with shoveling, water damage, and eventual flooding. The chronic nature of the 2010 winter season has also caused our mood to sour.

Chronic stress can certainly cause changes in the brain. Research indicates this can occur in the form of structural and chemical change. Post-traumatic stress disorder is one type of psychological disorder caused by a life-threatening stressor though reduced efficiency and functionality can also be caused by an unrelenting stressor in our lives. One aspect of the chemical alteration in our brains is a change in our moods. This might mean a clinical disorder such as depression or seasonal affective disorder or a more mild change such as increased irritability, fatigue, frustration, and a sense of hopelessness. Mother Nature is in charge!

It is important to recognize your own situation and how you and your loved ones may be coping with such a difficult winter. For those of us who are not “winter people” this can be a difficult challenge. Some coping mechanisms to consider include:

1.    Remember spring is getting closer each day.
2.    Use the down time to engage in family activities.
3.    Get some work done organizing or cleaning the house.
4.    Try to recreate in the snow as a family.
5.    Shovel the snow as a family (if you are physically able shoveling is a good exercise, but remember to bend your knees     and proceed in small steps).
6.    Build a fire if you have a fireplace and enjoy the moment.
7.    Use relaxation and meditation daily to cope.
8.    Be conscious of how you are feeling.
9.    Talk to your doctor about light therapy if needed.
10.    Spring is getting closer each day.

Bundle up and we will get through this together.

Awareness in Alzheimer’s Disease

Alzheimer’s disease (AD) is the leading cause of progressive dementia in the United States accounting for 95% of all dementias. It is believed that approximately 5 million Americans suffer AD and that this number will nearly triple in the next 40 years. AD is also on the increase worldwide.

AD is a progressive dementia that affects functions of memory, language, spatial skill, personality and functional ability. The disease continues to erode these functions rendering the patient completely dependent. It is generally believed that patients with more advanced AD are not aware of their condition and do not have an awareness of the people or places around them.

New research on awareness in those with vegetative state suggests this may not be true. Communication may also be possible for those in vegetative state. One case of a 29 year-old patient in a vegetative state was able to answer yes no questions by visualizing specific scenes the doctors asked him to imagine. The brain yielded different activity when different scenes were viewed. This particular patient was in a vegetative state for five years.

This new study published in the online version of the New England Journal of Medicine supports previous cases of awareness in those with vegetative state and raises significant issues concerning understanding of brain function and ethical matters dealing with end of life decisions.

Another suspicion this raises for me is whether a patient with advanced Alzheimer’s disease maintains some awareness of his surroundings. Perhaps the patient’s smile or blink to a family member has more meaning than we previously believed. It is not unreasonable to believe that the complexity of the human brain will not permit complete disconnect from those persons or things that are most important to that brain. We may simply not yet have the ability to measure such activity.

The new study reported in the online New England Journal of Medicine will help to spur research into this and other questions. We are on the frontier of an entirely new understanding of the human brain and we will be very surprised by how we have underestimated its ability and power. I refer to this new exploration of human brain potential as “neural energies.”

Intimacy, Affairs, and the Brain

I read with some interest a recent article in The Wall Street Journal Tuesday, November 3, 2009 about caregivers of spouses with Alzheimer’s Disease (AD) who find new companions for love. The article questioned whether such behavior could be considered adultery?

We have nearly 5 million Americans with AD and at least that many at risk. The number of those with AD will likely continue to grow to as many as 15 million by 2050. A recent survey reported there will be nearly 35 million with AD across the planet. Many of those suffering AD are married and the healthy spouse can serve the role of caregiver for many years, including a significant amount of time when their spouse with AD no longer recognizes them. The role of caregiver is difficult and ripe with emotional, physical, and financial stress. The article in the Wall Street Journal raises another stressor which is the idea that the healthy spouse may be without intimacy, love, and companionship for many years.

It is nearly impossible to understand how emotionally difficult it must be to care for a spouse with AD. Some describe AD as two deaths, one when you are told about the diagnosis and the second with the actual physical death of your loved one. Along the course of AD, a spouse will no longer recognize his or her partner. A healthy spouse who provides care to their partner with AD is vulnerable to loneliness, depression, and ongoing loss. How does one cope with loss of the emotional connection or loss of love in the traditional sense when your spouse is physically still present?

The Journal article raises many thoughts and ideas that do not have easy answers. I think it points out that we need to support even more our caregivers who dedicate so much of their time to their spouses with AD.

One Meal A Day with Others for Brain Health

I often am asked what one thing is most important for brain health promotion. I cannot answer this question because I do not believe there is such a thing. The human brain requires a comprehensive and integrated approach to health which is why I have developed my five part brain health lifestyle (see www.paulnussbaum.com).

I do believe that eating one meal a day with family members or even friends and those you may not know very well (be safe first) can be a major brain health activity. Sitting down to a meal helps you to slow down, you can listen to some music in the background, and tell stories over your meal. You can also use utensils that typically means you will eat healthier and eat less than when you eat with your fingers. These are several brain health boosts with one activity.

It is good to learn from Rasmussen Surveys that 65% of those surveyed by telephone eat with their family twice weekly. 38% eat a meal three times a week with their family and 27% report eating between two and three times weekly with their family. Only 22% do not eat with their family during the week.

I encourage everyone to carve out the special time necessary to sit down and eat a meal with your loved ones on a daily basis. Your brain and body will thank you.

Brainy Cities

A recent article in US News discussed the brain health of all 50 states and the District of Columbia in the United States. An index that was comprised of diet (36%), physical health (25%), mental health (24%), and social well being (15%) was used to compare the states. Data was gathered from the Centers for Disease Control and Prevention, the National Institute of Health, and the Bureau of Labor Statistics.

Results from the study revealed the following top ten brainiest cities:

1.    Washington DC
2.    Maryland
3.    Washington State
4.    Vermont
5.    Connecticut
6.    Colorado
7.    Massachusetts
8.    New Jersey
9.    Maine
10.  New Hampshire

It is important to be proactive in your brain health lifestyle. Dr. Nussbaum (www.paulnussbaum.com), Chief Scientific Officer for Fitbrains, Inc. underscores the importance of a brain health lifestyle that includes socialization, nutrition, physical activity, mental stimulation, and spirituality.

Football and the Brain

A recent study supported by the National Football League indicates that Alzheimer’s Disease (AD) or related conditions involving memory deficits appear to occur more frequently in the league’s former players significantly more than the general population. Indeed, the study indicates former players suffer dementia 19 times more often than the normal rate for men ages 30-49.

The study conducted by the University of Michigan’s Institute for Social Research is consistent with previous studies pertaining to NFL players and the effects of head injury. The study found that 6.1% of players age 50 and above reported that they had received a dementia-related diagnosis or 5x higher than the cited national average which is 1.2 %. Players ages 30 through 49 evinced a rate of 1.9% or 19 times that of the national average which is documented to be .01%.

Critics of the study question its methodology that reportedly used telephone surveys. However, research beyond the NFL consistently lists head injury as a risk factor for AD even though the exact mechanism for this relationship is not yet known.

Perhaps a more significant issue that the NFL/Dementia study underscores is the cumulative effect of head injury which likely begins with the sport of football well before any single player enters the NFL. Fortunately there are now sophisticated assessment protocols that provide each player in high school the opportunity to have his or her cognitive skills measured, thereby providing a baseline of their cognitive status. In the event a concussion occurs the player can obtain another assessment to measure the impact of the head injury that helps to keep the player off the field until his or her cognitive status returns to baseline.

It is most likely not a good idea to engage in any activity that has persistent striking of the head to any degree. Head injuries occur in football, hockey, and perhaps even soccer. The fact that the latter sport does not permit use of head bands or some type of head gear is amazing! The current study should alert the nation to re-consider youth sports as the cumulative effect of striking the head across the lifespan most likely contributes to the results reported. Equally significant is the idea that any child would be exposed to a potential head injury when his or her brain is undergoing critical development.

Mind Training in the Military

Mind training and meditation is now being used by some parts of the military. The mind body connection is now being recognized by military leaders to teach soldiers how to build confidence, set goals and channel their energy to a higher focus. The benefits of such training include better aim on the shooting range, higher test scores, enhanced ability to handle combat stress and to adjust back to civilian life. In fact nearly 70% of a small sample of soldiers who completed the training reported they felt better able to handle stressful situations and 66% had improved self control.

Neural energies is a term I use to describe the brain’s ability to modify or control internal workings of the body and external experiences. The mind training is but a first step to more advanced neural energy utilization that we will witness in the near future.